Unknown,Transcriptomics,Genomics,Proteomics

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Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network


ABSTRACT: Yeast cell cycle transcription dynamics in two S. cerevisae strains grown at 37°C: BF264-15DU (MATa ade1 his2 leu2-3, 112 trp1-1 ura3Dns, bar1) (wild type) and a mutant of the wild type strain lacking all Cdk1 activity, cdc28-4. We compared transcript levels of genes previously shown to be periodically expressed in wild-type cells (Orlando et al, 2008, Nature) to transcript levels in the absence of Cdk1 activity. Two replicate time courses from cells lacking all Cdk1 activity and one control time course from cells with wild-type Cdk1 activity are included.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Laura Simmons Kovacs 

PROVIDER: E-GEOD-32974 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network.

Simmons Kovacs Laura A LA   Mayhew Michael B MB   Orlando David A DA   Jin Yuanjie Y   Li Qingyun Q   Huang Chenchen C   Reed Steven I SI   Mukherjee Sayan S   Haase Steven B SB  

Molecular cell 20120202 5


During embryonic cell cycles, B-cyclin-CDKs function as the core component of an autonomous oscillator. Current models for the cell-cycle oscillator in nonembryonic cells are slightly more complex, incorporating multiple G1, S phase, and mitotic cyclin-CDK complexes. However, periodic events persist in yeast cells lacking all S phase and mitotic B-cyclin genes, challenging the assertion that cyclin-CDK complexes are essential for oscillations. These and other results led to the proposal that a n  ...[more]

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