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Genome-wide chromatin state maps of ES cells, ES-derived neural progenitor cells and brain tissue

ABSTRACT: Genome-wide chromatin state maps of murine embryonic stem (ES) cells, ES-derived neural progenitor cells and whole brain tissue. The data were generated to examine the correlation between histone and DNA methylation during lineage-commitment. Keywords: High-throughput ChIP-sequencing, Illumina, cell type comparison H3K4me3, H3K4me2 and/or H3K4me1 ChIP-Seq in singlicate from mouse embryonic stem (ES) cells, ES-derived neural progenitor cells and whole brain tissue suspensions Raw sequence data files for this study are available for download from the SRA FTP site at ftp://ftp.ncbi.nlm.nih.gov/sra/Studies/SRP000/SRP000230

ORGANISM(S): Mus musculus

SUBMITTER: Tarjei Mikkelsen

PROVIDER: E-GEOD-11172 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-scale DNA methylation maps of pluripotent and differentiated cells.

Meissner Alexander A Mikkelsen Tarjei S TS Gu Hongcang H Wernig Marius M Hanna Jacob J Sivachenko Andrey A Zhang Xiaolan X Bernstein Bradley E BE Nusbaum Chad C Jaffe David B DB Gnirke Andreas A Jaenisch Rudolf R Lander Eric S ES

Nature 20080706 7205

DNA methylation is essential for normal development and has been implicated in many pathologies including cancer. Our knowledge about the genome-wide distribution of DNA methylation, how it changes during cellular differentiation and how it relates to histone methylation and other chromatin modifications in mammals remains limited. Here we report the generation and analysis of genome-scale DNA methylation profiles at nucleotide resolution in mammalian cells. Using high-throughput reduced represe ...[more]

PMID: 18600261

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Gene expression microarray for mouse ES cells vs. mouse ES cells treated with 48 hr N2B27

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