Transcription profiling of Drosophila to investigate the nodal points and complexity of Notch-Ras signal integration

ABSTRACT: Metazoans utilize a handful of highly conserved signaling pathways to create a signaling backbone that governs all stages of development, by providing spatial and temporal cues that influence gene expression. How these few signals have such a versatile developmental action is of significance to evolution, development, and disease. Their versatility likely depends upon the larger-scale network they form through integration. Such integration is exemplified by cross-talk between the Notch and the Receptor Tyrosine Kinase (RTK) pathways. We examined the transcriptional output of Notch-RTK cross-talk during Drosophila development and present in vivo data that supports a role for selected mutually-regulated genes as potentially important nodal points for signal integration. We find the complex

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Gregory Hurlbut 

PROVIDER: E-GEOD-11203 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress