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Colon biopsies from UC patients and healthy controls

ABSTRACT: Transcriptional profiling of colon epithelial biopsies from ulcerative colitis patients and healthy control donors. Study aims to survey and analyze variation from disease in different GI regions. Keywords: disease state analysis Biopsies from a variety of anatomic locations, from patients of various treatment status or healthy controls.

ORGANISM(S): Homo sapiens

SUBMITTER: Alex Abbas

PROVIDER: E-GEOD-11223 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis.

Noble C L CL Abbas A R AR Cornelius J J Lees C W CW Ho G-T GT Toy K K Modrusan Z Z Pal N N Zhong F F Chalasani S S Clark H H Arnott I D ID Penman I D ID Satsangi J J Diehl L L

Gut 20080603 10

<h4>Objective</h4>To investigate differential intestinal gene expression in patients with ulcerative colitis and in controls.<h4>Design</h4>Genome-wide expression study (41,058 expression sequence tags, 215 biopsies).<h4>Setting</h4>Western General Hospital, Edinburgh, UK, and Genentech, San Francisco, USA.<h4>Patients</h4>67 patients with ulcerative colitis and 31 control subjects (23 normal subjects and 8 patients with inflamed non-inflammatory bowel disease biopsies).<h4>Interventions</h4>Pai ...[more]

PMID: 18523026

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