Unknown,Transcriptomics,Genomics,Proteomics

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Peripheral blood stem cell gene profiling


ABSTRACT: Mobilized-peripheral blood hematopoietic stem cells (HSCs) have been used for transplantation, immunotherapy, and cardiovascular regenerative medicine. Agents used for HPC mobilization include G-CSF and the CXCR4 inhibitor AMD3100. The HSCs cells mobilized by each agent may contain different subtypes and have different functions. To characterize mobilized HSCs used for clinical applications, microRNA (miRNA) profiling and gene expression profiling were used to compare AMD3100-mobilized CD133+ cells from 4 subjects, AMD3100 plus G-CSF-mobilized CD133+ cells from 4 subjects and G-CSF-mobilized CD34+ cells from 5 subjects. The HSCs were compared to peripheral blood leukocytes (PBLs) from 7 subjects. Keywords: cell type comparison design gene expression profiling were used to compare AMD3100-mobilized CD133+ cells from 4 subjects, AMD3100 plus G-CSF-mobilized CD133+ cells from 4 subjects and G-CSF-mobilized CD34+ cells from 5 subjects. The HSCs were compared to peripheral blood leukocytes (PBLs) from 7 subjects.

ORGANISM(S): Homo sapiens

SUBMITTER: Francesco Marincola 

PROVIDER: E-GEOD-11247 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Differentiation of two types of mobilized peripheral blood stem cells by microRNA and cDNA expression analysis.

Jin Ping P   Wang Ena E   Ren Jiaqiang J   Childs Richard R   Shin Jeong Won JW   Khuu Hanh H   Marincola Francesco M FM   Stroncek David F DF  

Journal of translational medicine 20080722


<h4>Background</h4>Mobilized-peripheral blood hematopoietic stem cells (HSCs) have been used for transplantation, immunotherapy, and cardiovascular regenerative medicine. Agents used for HSC mobilization include G-CSF and the CXCR4 inhibitor AMD3100 (plerixafor). The HSCs cells mobilized by each agent may contain different subtypes and have different functions. To characterize mobilized HSCs used for clinical applications, microRNA (miRNA) profiling and gene expression profiling were used to com  ...[more]

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