Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Peripheral blood stem cell gene and microRNA profiling

ABSTRACT: Mobilized-peripheral blood hematopoietic stem cells (HSCs) have been used for transplantation, immunotherapy, and cardiovascular regenerative medicine. Agents used for HPC mobilization include G-CSF and the CXCR4 inhibitor AMD3100. The HSCs cells mobilized by each agent may contain different subtypes and have different functions. To characterize mobilized HSCs used for clinical applications, microRNA (miRNA) profiling and gene expression profiling were used to compare AMD3100-mobilized CD133+ cells from 4 subjects, AMD3100 plus G-CSF-mobilized CD133+ cells from 4 subjects and G-CSF-mobilized CD34+ cells from 5 subjects. The HSCs were compared to peripheral blood leukocytes (PBLs) from 7 subjects. This SuperSeries is composed of the following subset Series: GSE11247: Peripheral blood stem cell gene profiling GSE11248: Peripheral blood stem cell microRNA profiling Keywords: SuperSeries Refer to individual Series

ORGANISM(S): Human herpesvirus 4

SUBMITTER: Francesco Marincola

PROVIDER: E-GEOD-11255 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Differentiation of two types of mobilized peripheral blood stem cells by microRNA and cDNA expression analysis.

Jin Ping P Wang Ena E Ren Jiaqiang J Childs Richard R Shin Jeong Won JW Khuu Hanh H Marincola Francesco M FM Stroncek David F DF

Journal of translational medicine 20080722

<h4>Background</h4>Mobilized-peripheral blood hematopoietic stem cells (HSCs) have been used for transplantation, immunotherapy, and cardiovascular regenerative medicine. Agents used for HSC mobilization include G-CSF and the CXCR4 inhibitor AMD3100 (plerixafor). The HSCs cells mobilized by each agent may contain different subtypes and have different functions. To characterize mobilized HSCs used for clinical applications, microRNA (miRNA) profiling and gene expression profiling were used to com ...[more]

PMID: 18647411

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Dataset Information

Peripheral blood stem cell gene and microRNA profiling

Publications

Differentiation of two types of mobilized peripheral blood stem cells by microRNA and cDNA expression analysis.

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