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MGAS5005 vs MGAS5005∆ccpA

ABSTRACT: The aim of this study was to determine the extent of the CcpA regulon in the M1 serotype MGAS5005. Kinkel and McIver, 2008 Infection and Immunity Keywords: group A streptococcus, CcpA 3 biological replicates of MGAS5005 and the isogenic ∆ccpA strain were grown, and RNA was isolated independently 3 times. The RNA was converted to cDNA and labeled with with either Cy3 or Cy5 using the GE Healthcare CyScribe Post-labelling kit. The arrays were scanned with GenePix 6.1 and analyzed with Acuity 4.0.

ORGANISM(S): Streptococcus pyogenes

SUBMITTER: Kevin McIver 

PROVIDER: E-GEOD-11328 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

CcpA-mediated repression of streptolysin S expression and virulence in the group A streptococcus.

Kinkel Traci L TL   McIver Kevin S KS  

Infection and immunity 20080519 8

CcpA is the global mediator of carbon catabolite repression (CCR) in gram-positive bacteria, and growing evidence from several pathogens, including the group A streptococcus (GAS), suggests that CcpA plays an important role in virulence gene regulation. In this study, a deletion of ccpA in an invasive M1 GAS strain was used to test the contribution of CcpA to pathogenesis in mice. Surprisingly, the DeltaccpA mutant exhibited a dramatic "hypervirulent" phenotype compared to the parental MGAS5005  ...[more]

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