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M1 MGAS5005 TrxR+ vs. TrxR- mutant

ABSTRACT: The aim of this study was to determine the extent of the trxR regulon in the M1 serotype MGAS5005. Gold, Leday, McIver 2008 Keywords: Wild-type vs trxR- series contains MGAS5005 and MGAS5005.trxR (trxR-) from three independent isolations. cDNA ratios from these isolations as well as their dye swap included

ORGANISM(S): Streptococcus pyogenes

SUBMITTER: Kevin McIver

PROVIDER: E-GEOD-11388 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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TrxR, a new CovR-repressed response regulator that activates the Mga virulence regulon in group A Streptococcus.

Leday Temekka V TV Gold Kathryn M KM Kinkel Traci L TL Roberts Samantha A SA Scott June R JR McIver Kevin S KS

Infection and immunity 20080804 10

Coordinate regulation of virulence factors by the group A streptococcus (GAS) Streptococcus pyogenes is important in this pathogen's ability to cause disease. To further elucidate the regulatory network in this human pathogen, the CovR-repressed two-component system (TCS) trxSR was chosen for further analysis based on its homology to a virulence-related TCS in Streptococcus pneumoniae. In a murine skin infection model, an insertion mutation in the response regulator gene, trxR, led to a signific ...[more]

PMID: 18678666

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