Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human nasal epithelium from subjects infected with HRV-16 rhinovirus vs sham infected


ABSTRACT: This study provides a comprehensive evaluation of changes in gene expression during rhinovirus infections in vivo. Subjects were experimentally infected with HRV-16 rhinovirus (RV16) or sham infected (control). Nasal epithelial scrapings collected and processed for microarray analysis. Only subjects exhibiting rhinovirus infection were analyzed. Experiment Overall Design: Randomized, parallel group study. A total of 31 subjects was analyzed: 15 infected and 16 controls. Nasal scapings were taken 14 days prior to infection (d14) and 8 hours (d0) and 2 days (d2) after infection. For each collection, alternating nostrils were used (e.g. -14d = left, 8hr = right, 2d=left) and subjects were randomized for collection (e.g. LRL, RLR).

ORGANISM(S): Homo sapiens

SUBMITTER: Jay Patrick Tiesman 

PROVIDER: E-GEOD-11348 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression profiles during in vivo human rhinovirus infection: insights into the host response.

Proud David D   Turner Ronald B RB   Winther Birgit B   Wiehler Shahina S   Tiesman Jay P JP   Reichling Tim D TD   Juhlin Kenton D KD   Fulmer Andy W AW   Ho Begonia Y BY   Walanski Amy A AA   Poore Cathy L CL   Mizoguchi Haruko H   Jump Lynn L   Moore Marsha L ML   Zukowski Claudine K CK   Clymer Jeffrey W JW  

American journal of respiratory and critical care medicine 20080724 9


<h4>Rationale</h4>Human rhinovirus infections cause colds and trigger exacerbations of lower airway diseases.<h4>Objectives</h4>To define changes in gene expression profiles during in vivo rhinovirus infections.<h4>Methods</h4>Nasal epithelial scrapings were obtained before and during experimental rhinovirus infection, and gene expression was evaluated by microarray. Naturally acquired rhinovirus infections, cultured human epithelial cells, and short interfering RNA knockdown were used to furthe  ...[more]

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