Dataset Information

In-depth proteomic analysis of nasal fluids from patients with chronic rhinosinusitis and nasal polyps by data-independent acqusition

ABSTRACT: Antibiotics are commonly prescribed to treat chronic rhinosinusitis (CRS). However, the effects of antibiotics on the microbiome and secreted proteome remain unknown in regard to CRS.We analyzed the effects of antibiotics on the nasal secreted proteome inthe context of CRS using data-independent acqusition proteomics approach.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Nasal Lavage Fluid, Epithelial Cell

SUBMITTER: Dohyun Han

LAB HEAD: Dohyun Han

PROVIDER: PXD018960 | Pride | 2021-09-09

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	20191102_161438_CRS_reprocessing_Report.xls	Xls
	20191103_183621_CRS_reprocessing.sne	Other
	CON_04_DIA_1.raw	Raw
	CON_04_DIA_2.raw	Raw
	CON_08_DIA_1.raw	Raw

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Publications

Antibiotic-Dependent Relationships Between the Nasal Microbiome and Secreted Proteome in Nasal Polyps.

Kim Yi Sook YS Han Dohyun D Mo Ji Hun JH Kim Yong Min YM Kim Dae Woo DW Choi Hyo Guen HG Park Jong Wan JW Shin Hyun Woo HW

Allergy, asthma & immunology research 20210701 4

<h4>Purpose</h4>Chronic rhinosinusitis (CRS) is a heterogeneous chronic inflammatory condition of the paranasal sinuses and nasal passages. Although antibiotics are used to reduce inflammation or to treat an episode of acute rhinosinusitis, their effects on the nasal environment and host response in CRS is unclear.<h4>Methods</h4>We analyzed the effects of antibiotics on the nasal microbiome and secreted proteome in CRS using multi-omic analysis. Nasal secretions were collected from 29 controls, ...[more]

PMID: 34212546

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