Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Xinkun Wang
PROVIDER: E-GEOD-11419 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wang Xinkun X Bao Xiaodong X Pal Ranu R Agbas Abdulbaki A Michaelis Elias K EK
BMC genomics 20100607
<h4>Background</h4>Increases during aging in extracellular levels of glutamate (Glu), the major excitatory neurotransmitter in the brain, may be linked to chronic neurodegenerative diseases. Little is known about the molecular responses of neurons to chronic, moderate increases in Glu levels. Genome-wide gene expression in brain hippocampus was examined in a unique transgenic (Tg) mouse model that exhibits moderate Glu hyperactivity throughout the lifespan, the neuronal Glutamate dehydrogenase ( ...[more]