Unknown,Transcriptomics,Genomics,Proteomics

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GeneChip expression profiling of Glud1 (glutamate dehydrogenase 1) transgenic mice


ABSTRACT: Glud1 (glutamate dehydrogenase 1) transgenic mice release more excitatory neurotransmitter glutamate to synaptic cleft throughout lifespan and show signs of accelerated aging. Here we compared transcriptomic profiles of these animals to their wild-type counterparts. The hippocampus was used for the analysis. Keywords: transgenic analysis Three Glud1 transgenic mice vs. three age-matched wide-type mice. Age: 9-month-old. Tissue: hippocampus.

ORGANISM(S): Mus musculus

SUBMITTER: Xinkun Wang 

PROVIDER: E-GEOD-11419 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.

Wang Xinkun X   Bao Xiaodong X   Pal Ranu R   Agbas Abdulbaki A   Michaelis Elias K EK  

BMC genomics 20100607


<h4>Background</h4>Increases during aging in extracellular levels of glutamate (Glu), the major excitatory neurotransmitter in the brain, may be linked to chronic neurodegenerative diseases. Little is known about the molecular responses of neurons to chronic, moderate increases in Glu levels. Genome-wide gene expression in brain hippocampus was examined in a unique transgenic (Tg) mouse model that exhibits moderate Glu hyperactivity throughout the lifespan, the neuronal Glutamate dehydrogenase (  ...[more]

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