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Glutamate-induced transcriptional changes in embryonic mouse cortical neurons [GRO-seq]

ABSTRACT: Glutamate is a major excitatory neurotransmitter in the nervous system. Increased and persistent release of glutamate is toxic to neurons and this excitotoxicity is a hallmark of several neurodegenerative diseases. Here, we use GRO-seq to screen for the acute transcriptional changes induced by glutamate exposure on embryonic mouse cortical neurons to reveal downstream molecules which could participate in glutamate-induced toxicity. We show that several miRNA genes, such as miR-21, have altered expression upon glutamate exposure.

ORGANISM(S): Mus musculus

PROVIDER: GSE215210 | GEO | 2023/01/03

REPOSITORIES: GEO

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