Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Raffaele De Palma
PROVIDER: E-GEOD-11553 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cosmi Lorenzo L De Palma Raffaele R Santarlasci Veronica V Maggi Laura L Capone Manuela M Frosali Francesca F Rodolico Gabriella G Querci Valentina V Abbate Gianfranco G Angeli Roberta R Berrino Liberato L Fambrini Massimiliano M Caproni Marzia M Tonelli Francesco F Lazzeri Elena E Parronchi Paola P Liotta Francesco F Maggi Enrico E Romagnani Sergio S Annunziato Francesco F
The Journal of experimental medicine 20080728 8
We demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T helper cell (Th17) clones and that all IL-17-producing cells are contained in the CD161(+) fraction of CD4(+) T cells present in the circulation or in inflamed tissues, although they are not CD1-restricted natural killer T cells. More importantly, we show that all IL-17-producing cells originate from CD161(+) naive CD4(+) T cells of umbilical cord blood, as well as of the postnatal thymus, in response to the c ...[more]