Ontology highlight
ABSTRACT:
ORGANISM(S): Escherichia coli
SUBMITTER: Cornelia GroÃ?e
PROVIDER: E-GEOD-11562 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Helbig Kerstin K Grosse Cornelia C Nies Dietrich H DH
Journal of bacteriology 20080606 15
The higher affinity of Cd(2+) for sulfur compounds than for nitrogen and oxygen led to the theoretical consideration that cadmium toxicity should result mainly from the binding of Cd(2+) to sulfide, thiol groups, and sulfur-rich complex compounds rather than from Cd(2+) replacement of transition-metal cations from nitrogen- or oxygen-rich biological compounds. This hypothesis was tested by using Escherichia coli for a global transcriptome analysis of cells synthesizing glutathione (GSH; wild typ ...[more]