Dataset Information
Time course RA-treatment of B16 mouse melanoma cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: James Denvir
PROVIDER: E-GEOD-11580 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Global analysis of gene expression changes during retinoic acid-induced growth arrest and differentiation of melanoma: comparison to differentially expressed genes in melanocytes vs melanoma.
BMC genomics 20081011
<h4>Background</h4>The incidence of malignant melanoma has significantly increased over the last decade. Some of these malignancies are susceptible to the growth inhibitory and pro-differentiating effects of all-trans-retinoic acid (RA). The molecular changes responsible for the biological activity of RA in melanoma are not well understood.<h4>Results</h4>In an analysis of sequential global gene expression changes during a 4-48 h RA treatment of B16 mouse melanoma cells, we found that RA increas ...[more]
