Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of mouse of melan-a mouse melanocytes vs. B16 melanoma cells

ABSTRACT: Gene expression profile of melan-a mouse melanocytes vs. B16 mouse melanoma cells. Experiment Overall Design: Balanced block design with dye swap. Six biological replicates, one replicate per array.

ORGANISM(S): Mus musculus

SUBMITTER: James Denvir

PROVIDER: E-GEOD-11584 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Melan-a melanocytes and B16 melanoma cells

Project description:This SuperSeries is composed of the following subset Series: GSE11580: Time course RA-treatment of B16 mouse melanoma cells GSE11584: Melan-a mouse melanocytes vs. B16 mouse melanoma cells Keywords: SuperSeries Refer to individual Series

2008-07-31 | E-GEOD-11588 | biostudies-arrayexpress

Melan-a mouse melanocytes vs. B16 mouse melanoma cells

Project description:Gene expression profile of melan-a mouse melanocytes vs. B16 mouse melanoma cells. Keywords: Cell type comparison

2008-07-31 | GSE11584 | GEO

SEMA3E-PLXND1 induced transcriptional changes in B16 melanocytes

Project description:Exposure to SEMA3E cause an immediate but transient collapse in F-actin of B16 melanocytes expressing the receptor PLXND1. Concomitant signal transduction by activated PLXND1 receptor mediated via its GTPase activating domain has a role in adapting the melanocytes to its micro-environment. To analyse these adaptive transcriptional responses B16 melanocytes were treated with SEMA3E for 2h to study early responses and for 8h to study prolonged responses. Cytochalasin D (8h) was used to distinguish the effects brough about by cytoskeletal collapse alone.

2024-07-01 | GSE189438 | GEO

Transcriptome and gene/transcript expression profiling in melan-a cells

Project description:The melan-a cell line is derived from immortalized mouse melanocytes obtained from Ink4a-ARF-/- mice. RNA-seq was performed to assess the global nature of transcript and gene expression profiles in melan-a cells. These RNA-seq data, along with separate ChIP-seq performed in melan-a cells (GSE38498), were used to correlate gene expression patterns with the presence or absence of transcription factors of interest.

2016-09-18 | GSE87051 | GEO

Microarray analysis of the effects of ASP/MSH in melan-a melanocytes

2009-02-03 | GSE14089 | GEO

SEMA3E-PLXND1 induced transcriptional changes in B16 melanocytes

Project description:SEMA3E-PLXND1 induced transcriptional changes in B16 melanocytes

| PRJNA783012 | ENA

ChIP-seq for EP300 and H3K4me1 in the mouse melanocyte cell line melan-a

Project description:Using ChIP-seq for p300 and H3K4me1, we identified 2,489 putative melanocyte enhancer loci in the mouse genome. We demonstrated that these putative enhancers are evolutionarily constrained, enriched for sequence motifs predicted to bind key melanocyte transcription factors, located near genes relevant to melanocyte biology, and capable of driving reporter gene expression with high frequency in cultured melanocytes and in melanocytes of transgenic zebrafish. ChIP-seq for EP300 and H3K4me1 in the mouse melanocyte cell line melan-a.

2012-09-14 | E-GEOD-38498 | biostudies-arrayexpress

Project description:Melan-a melanocytes and B16 melanoma cells

| PRJNA106221 | ENA

Microarray analysis of the effects of ASP/MSH in melan-a melanocytes

Project description:We determined the gene expression profiles of murine melan-a melanocytes treated with ASP or alpha-MSH over a 4 days time course using genome-wide oligonucleotide microarrays. As expected, the gene expression patterns emphasized the opposing effects of the 2 ligands, and there were significant reductions in expression of numerous melanogenic proteins elicited by ASP, which correlates with its inhibition of pigmentation. However, ASP also unexpectidly modulated the expression of genes involved in various other cellular pathways, including glutathione synthesis and redox metabolism. Many genes up-regulated by ASP are involved in morphogenesis, cell adhesion and ECM-receptor interactions. Treatment with ASP or alpha-MSH was performed for 3 hr, 1 day, 2 days, 3 days and 4 days, in triplicate. Each biological replicate was submitted to a direct hybridization (treated/untreated samples) after coupling with Cy5 or Cy3 and to a reverse dye-swap, leading to 2 replicated hybridization for each biological sample. A total of 6 hybridized arrays was used for each of the 5 time points, for each drug.

2009-02-02 | E-GEOD-14089 | biostudies-arrayexpress

Melan-a melanocytes and B16 melanoma cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2008-07-31 | GSE11588 | GEO