SEMA3E-PLXND1 induced transcriptional changes in B16 melanocytes

ABSTRACT: Exposure to SEMA3E cause an immediate but transient collapse in F-actin of B16 melanocytes expressing the receptor PLXND1. Concomitant signal transduction by activated PLXND1 receptor mediated via its GTPase activating domain has a role in adapting the melanocytes to its micro-environment. To analyse these adaptive transcriptional responses B16 melanocytes were treated with SEMA3E for 2h to study early responses and for 8h to study prolonged responses. Cytochalasin D (8h) was used to distinguish the effects brough about by cytoskeletal collapse alone.

ORGANISM(S): Mus musculus

PROVIDER: GSE189438 | GEO | 2024/07/01

REPOSITORIES: GEO