Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of mouse liver from tumor bearing animals by TSU68 treatment


ABSTRACT: The aim of this study was to investigate the inhibitory effect of TSU68, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor beta (PDGFRβ) and fibroblast growth factor receptor 1 (FGFR1), on colon cancer liver metastasis and to test the hypothesis that TSU68 modulates the microenvironment in the liver before the formation of metastasis. Experiment Overall Design: The human colon cancer TK-4 was implanted orthotopically into cecal walls of 6-week-old male BALB/c nu/nu mice (Clea Japan, Tokyo, Japan). The animals were treated with TSU68 (400 mg/kg/day, twice-daily, p.o.) or vehicle from 7 days after orthotopic implantation. After one week of drug administration, livers were removed and total RNA was extracted. Experiment Overall Design: We established four different groups of mice; non-tumor-bearing and treated with vehicle alone (NT-Co), non-tumor-bearing and treated with TSU68 (NT-TSU), tumor-bearing and treated with vehicle (T-Co), and tumor-bearing and treated with TSU68 (T-TSU). NT-Co, T-Co and T-TSU group were applied to microarray analysis.

ORGANISM(S): Mus musculus

SUBMITTER: M Yamamoto 

PROVIDER: E-GEOD-11808 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2016-06-22 | E-GEOD-83571 | biostudies-arrayexpress
2016-06-22 | GSE83571 | GEO
2013-10-14 | GSE44936 | GEO
2008-09-12 | E-GEOD-11981 | biostudies-arrayexpress
2022-12-31 | GSE197328 | GEO
2023-02-01 | GSE146222 | GEO
2021-11-10 | GSE171168 | GEO
2013-10-14 | E-GEOD-44936 | biostudies-arrayexpress
2014-08-24 | GSE50795 | GEO
2013-10-04 | E-GEOD-42049 | biostudies-arrayexpress