Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jeremy McIntyre
PROVIDER: E-GEOD-12135 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chemical senses 20081014 9
The mechanisms selecting a single odorant receptor (OR) gene for expression in each olfactory sensory neuron (OSN) establish an OR expression pattern critical for odor discrimination. These mechanisms are largely unknown, but putative OR promoters contain homeodomain-like sites, implicating homeobox transcription factors such as Emx2. At embryonic day 18.5, expression of 49-76% of ORs was decreased in mice lacking Emx2, depending on the metric used. The decreases were due to fewer OSNs expressin ...[more]