Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Noriko Shimasaki
PROVIDER: E-GEOD-12198 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cancer research 20090421 9
Infusions of natural killer (NK) cells are an emerging tool for cancer immunotherapy. The development of clinically applicable methods to produce large numbers of fully functional NK cells is a critical step to maximize the potential of this approach. We determined the capacity of the leukemia cell line K562 modified to express a membrane-bound form of interleukin (IL)-15 and 41BB ligand (K562-mb15-41BBL) to generate human NK cells with enhanced cytotoxicity. Seven-day coculture with irradiated ...[more]