Unknown,Transcriptomics,Genomics,Proteomics

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Primary NKcells vs. NKAES-derived NK cells vs. NKcells stimulated by low/high dose IL2 after 7days of culture


ABSTRACT: Transcriptional profiling of NKAES-derived NK cells after 7 days of culture compared to primary human NK cells and NK cells stimulated by low or high dose IL2 after 7 days of culture. Four-condition experiment, primary NK cells vs. NKAES-derived NK cells after 7 days of culture vs. NK cells stimulated by low/high dose IL2 after 7 days of culture. Biological replicates: 5 control, 5 NKAES-derived NK cells, 3 NK cells stimulated by low dose IL2, 3 NK cells stimulated by high dose IL2 independently grown and harvested. One replicate per array.

ORGANISM(S): Homo sapiens

SUBMITTER: Noriko Shimasaki 

PROVIDER: E-GEOD-12198 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Expansion of highly cytotoxic human natural killer cells for cancer cell therapy.

Fujisaki Hiroyuki H   Kakuda Harumi H   Shimasaki Noriko N   Imai Chihaya C   Ma Jing J   Lockey Timothy T   Eldridge Paul P   Leung Wing H WH   Campana Dario D  

Cancer research 20090421 9


Infusions of natural killer (NK) cells are an emerging tool for cancer immunotherapy. The development of clinically applicable methods to produce large numbers of fully functional NK cells is a critical step to maximize the potential of this approach. We determined the capacity of the leukemia cell line K562 modified to express a membrane-bound form of interleukin (IL)-15 and 41BB ligand (K562-mb15-41BBL) to generate human NK cells with enhanced cytotoxicity. Seven-day coculture with irradiated  ...[more]

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