Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kevin Becker
PROVIDER: E-GEOD-12215 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Mazan-Mamczarz Krystyna K Hagner Patrick R PR Dai Bojie B Wood William H WH Zhang Yongqing Y Becker Kevin G KG Liu Zhenqui Z Gartenhaus Ronald B RB
Cancer research 20081001 19
The aberrant expression of many genes is a common feature in the malignant transformation of cells. In mammalian cells, posttranscriptional gene regulatory processes are emerging as critical determinants controlling gene expression both in physiologic and pathologic conditions. These regulatory mechanisms are directed primarily by the interaction of mRNAs with specific RNA-binding proteins (RBP). There is an emerging body of data demonstrating that two RBPs, AUF1 and HuR, can antagonistically af ...[more]