Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide molecular characterisation of CNS PNET and Pineoblastoma


ABSTRACT: sPNETs are highly malignant embryonal brain tumours of poor prognosis. The underlying biology is poorly understood. To address this we therefore performed high resolution genetic analysis. 36 CNS PNETs and 8 PBs were analysed using the Affymetrix 100K and 500K Mapping Set to identify copy number imbalance at both the chromosome and gene level. Keywords: Affymetrix 100K SNP array, Affymetrix 500K SNP arrays 36 CNS PNETs and 8 PBs with constitutional controls

ORGANISM(S): Homo sapiens

SUBMITTER: Suzanne Miller 

PROVIDER: E-GEOD-12370 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Central nervous system primitive neuroectodermal tumor (CNS PNET) and pineoblastoma are highly malignant embryonal brain tumors with poor prognoses. Current therapies are based on the treatment of pediatric medulloblastoma, even though these tumors are distinct at both the anatomical and molecular level. CNS PNET and pineoblastoma have a worse clinical outcome than medulloblastoma; thus, improved therapies based on an understanding of the underlying biology of CNS PNET and pineoblastoma are need  ...[more]

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