Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis are prominent features of Aprataxin-deficient cells
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ABSTRACT: Ataxia with oculomotor apraxia type 1 (AOA1) is an early onset progressive spinocerebellar ataxia caused by mutation in aprataxin (APTX). Here we use RNA-seq to identify genes that are affected by APTX-KO, APTX overexpression, and APTX mutant, thus contributes to understadning the mechanisms underlying AOA1 pathlogy. Examination the chages of gene expressions in APTX proficient and APTX deficienc cells.
ORGANISM(S): Homo sapiens
SUBMITTER: Jin Zheng
PROVIDER: E-GEOD-124412 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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