Unknown,Transcriptomics,Genomics,Proteomics

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Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis are prominent features of Aprataxin-deficient cells


ABSTRACT: Ataxia with oculomotor apraxia type 1 (AOA1) is an early onset progressive spinocerebellar ataxia caused by mutation in aprataxin (APTX). Here we use RNA-seq to identify genes that are affected by APTX-KO, APTX overexpression, and APTX mutant, thus contributes to understadning the mechanisms underlying AOA1 pathlogy. Examination the chages of gene expressions in APTX proficient and APTX deficienc cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Jin Zheng 

PROVIDER: E-GEOD-124412 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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