HCT116 cells isogenic for p53 expression upon treatment with actinomycin D and nutlin-3
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Meng Ling Choong
PROVIDER: E-GEOD-12459 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy.
Choong Meng Ling ML Yang Henry H Lee May Ann MA Lane David P DP
Cell cycle (Georgetown, Tex.) 20090913 17
The activation of p53 has been proposed as a novel anti-cancer treatment in two distinct contexts. In the first activation of p53 in tumor cells can promote apoptosis and senescence and enhance the anti-tumor activity of cytotoxic chemotherapeutic drugs. In the second application activation of p53 in normal tissues can cause a reversible cell cycle arrest that can be used to protect normal cells from the action of anti-mitotics. In this cyclotherapy role p53 mutant tumor cells are not arrested a ...[more]
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