Specification of functional floor plate tissue from human embryonic stem cells occurs at the expense of anterior neurectoderm
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Stuart Chambers
PROVIDER: E-GEOD-20573 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Efficient derivation of functional floor plate tissue from human embryonic stem cells.
Fasano Christopher A CA Chambers Stuart M SM Lee Gabsang G Tomishima Mark J MJ Studer Lorenz L
Cell stem cell 20100401 4
The floor plate (FP) is a critical signaling center during neural development located along the ventral midline of the embryo. Little is known about human FP development because of the lack of tissue accessibility. Here we report the efficient derivation of human embryonic stem cell (hESC)-derived FP tissue capable of secreting Netrin-1 and SHH and patterning primary and hESC derived tissues. FP induction in hESCs is dependent on early SHH exposure and occurs at the expense of anterior neurectod ...[more]
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