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Genomic profiling of prostate cancer in African-American patients

ABSTRACT: African-Americans with prostate cancer tend to have a more aggressive form of the disease, as compared to their Caucasian counterparts. Nevertheless, African-Americans tend to be underrepresented in most molecular profiling studies of prostate cancer. To investigate DNA copy number alterations (CNAs) in prostate cancer from a cohort of African-Americans, we profiled 20 tumors (each with paired normal) for 500,000 SNPs. Keywords: tumor-normal comparison Profiles were generated on two Affymetrix array chips: Nsp and Sty, each with ~250K SNPs represented. In all, 20 tumors and 20 paired normal samples were profiled, 40 profiles in all. Each tumor was centered on its corresponding normal pair to define copy number alterations (CNA) in that tumor.

ORGANISM(S): Homo sapiens

SUBMITTER: Chad Creighton 

PROVIDER: E-GEOD-12702 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomic profiling of prostate cancers from African American men.

Castro Patricia P   Creighton Chad J CJ   Ozen Mustafa M   Berel Dror D   Mims Martha P MP   Ittmann Michael M  

Neoplasia (New York, N.Y.) 20090301 3

African American (AA) men have a higher incidence and significantly higher mortality rates from prostate cancer than white men, but the biological basis for these differences are poorly understood. Few studies have been carried out to determine whether there are areas of allelic loss or gain in prostate cancers from AA men that are overrepresented in or specific to this group. To better understand the molecular mechanisms of prostate cancer in AA men, we have analyzed 20 prostate cancers from AA  ...[more]

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