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PCMV-FAK vs pCMV in HU

ABSTRACT: CMV-driven FAK overexpression in soleus muscle was compared vs empty transfection in contralateral muscle after unloading paired comparison in contralateral leg

ORGANISM(S): Rattus norvegicus

SUBMITTER: Martin Flück 

PROVIDER: E-GEOD-12745 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Focal adhesion kinase is a load-dependent governor of the slow contractile and oxidative muscle phenotype.

Durieux Anne-Cécile AC   D'Antona Giuseppe G   Desplanches Dominique D   Freyssenet Damien D   Klossner Stephan S   Bottinelli Roberto R   Flück Martin M  

The Journal of physiology 20090526 Pt 14

Striated muscle exhibits a pronounced structural-functional plasticity in response to chronic alterations in loading. We assessed the implication of focal adhesion kinase (FAK) signalling in mechano-regulated differentiation of slow-oxidative muscle. Load-dependent consequences of FAK signal modulation were identified using a multi-level approach after electrotransfer of rat soleus muscle with FAK-expression plasmid vs. empty plasmid-transfected contralateral controls. Muscle fibre-targeted over  ...[more]

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