Dataset Information
Transcriptome analysis of rat soleus muscle after altered loading state and somatic overexpression of FAK
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Martin Flück
PROVIDER: E-GEOD-16466 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Focal adhesion kinase is a load-dependent governor of the slow contractile and oxidative muscle phenotype.
The Journal of physiology 20090526 Pt 14
Striated muscle exhibits a pronounced structural-functional plasticity in response to chronic alterations in loading. We assessed the implication of focal adhesion kinase (FAK) signalling in mechano-regulated differentiation of slow-oxidative muscle. Load-dependent consequences of FAK signal modulation were identified using a multi-level approach after electrotransfer of rat soleus muscle with FAK-expression plasmid vs. empty plasmid-transfected contralateral controls. Muscle fibre-targeted over ...[more]
