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Gene expression profiling in peripheral blood cells of patients with rheumatoid arthitis in response of anti-TNF-alpha

ABSTRACT: The goal of this study was to characterize the effects of anti-TNF-alpha treatments on gene expression in peripheral blood mononuclear cells. 8 women were submitted to a 12 weeks treatments with Etanercept or Adalimumab. Peripheral blood mononuclear cells were taken before and after the treatment. The samples from the same patients (obtained before and after the 12 weeks of treatment) were compared on the same microarray. Sample taken before the treatment was considered as the control. Blood mononuclear cells from 8 women suffering from rheumatoid arthritis were used in this study. The samples from the same patients (obtained before and after the 12 weeks of treatment) were compared on the same microarray. Mononuclear cells taken before the treatment was considered as the control.

ORGANISM(S): Homo sapiens

SUBMITTER: emmanuelle meugnier

PROVIDER: E-GEOD-12897 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling in peripheral blood cells of patients with rheumatoid arthritis in response to anti-TNF-alpha treatments.

Meugnier E E Coury F F Tebib J J Ferraro-Peyret C C Rome S S Bienvenu J J Vidal H H Sibilia J J Fabien N N

Physiological genomics 20110125 7

The efficacy of anti-TNF-α therapies highlights the role of TNF-α in the pathogenesis of rheumatoid arthritis (RA). However, the mechanism of action of these agents is poorly understood at the molecular level. The aim of this study was to characterize the effects of anti-TNF-α treatment on the global gene expression profile in peripheral blood mononuclear cells (PBMCs) of responder RA patients. Changes in gene expression were determined using oligonucleotide microarrays (25,341 genes) in PBMCs o ...[more]

PMID: 21266503

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