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Copy number analysis of human glioblastoma multiforme

ABSTRACT: Copy number analysis of human GBM samples were performed, and a high frequency of deletions of the PTPRD gene on chromosome 9p23-24.1 were identified. Keywords: SNP microarray, glioblastoma multiforme, copy number, amplification, deletion Genomic DNA from 58 GBM tumor samples were hybridized to Affymetrix 250K NspI Gene Chip Arrays and analyzed by dChip using the hg17 genome assembly.

ORGANISM(S): Homo sapiens

SUBMITTER: David Solomon

PROVIDER: E-GEOD-13021 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma.

Solomon David A DA Kim Jung-Sik JS Cronin Julia C JC Sibenaller Zita Z Ryken Timothy T Rosenberg Steven A SA Ressom Habtom H Jean Walter W Bigner Darell D Yan Hai H Samuels Yardena Y Waldman Todd T

Cancer research 20081201 24

An additional tumor suppressor gene on chromosome 9p telomeric to the CDKN2A/B locus has long been postulated to exist. Using Affymetrix 250K single nucleotide polymorphism arrays to screen for copy number changes in glioblastoma multiforme (GBM), we detected a high frequency of deletions of the PTPRD gene, which encodes a receptor protein tyrosine phosphatase at chromosome 9p23-24.1. Missense and nonsense mutations of PTPRD were identified in a subset of the samples lacking deletions, including ...[more]

PMID: 19074898

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