Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Christopher Vollmers
PROVIDER: E-GEOD-13063 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Vollmers Christopher C Gill Shubhroz S DiTacchio Luciano L Pulivarthy Sandhya R SR Le Hiep D HD Panda Satchidananda S
Proceedings of the National Academy of Sciences of the United States of America 20091125 50
In mammals, the circadian oscillator generates approximately 24-h rhythms in feeding behavior, even under constant environmental conditions. Livers of mice held under constant darkness exhibit circadian rhythm in abundance in up to 15% of expressed transcripts. Therefore, oscillations in hepatic transcripts could be driven by rhythmic food intake or sustained by the hepatic circadian oscillator, or a combination of both. To address this question, we used distinct feeding and fasting paradigms on ...[more]