Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Philipp Oberdoerffer
PROVIDER: E-GEOD-13121 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Oberdoerffer Philipp P Michan Shaday S McVay Michael M Mostoslavsky Raul R Vann James J Park Sang-Kyu SK Hartlerode Andrea A Stegmuller Judith J Hafner Angela A Loerch Patrick P Wright Sarah M SM Mills Kevin D KD Bonni Azad A Yankner Bruce A BA Scully Ralph R Prolla Tomas A TA Alt Frederick W FW Sinclair David A DA
Cell 20081101 5
Genomic instability and alterations in gene expression are hallmarks of eukaryotic aging. The yeast histone deacetylase Sir2 silences transcription and stabilizes repetitive DNA, but during aging or in response to a DNA break, the Sir complex relocalizes to sites of genomic instability, resulting in the desilencing of genes that cause sterility, a characteristic of yeast aging. Using embryonic stem cells, we show that mammalian Sir2, SIRT1, represses repetitive DNA and a functionally diverse set ...[more]