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MeDIP-chip from clinical cervical tissues in promoters

ABSTRACT: Utilizing methylation DNA immunoprecipitation (MeDIP) coupled with promoter tiling arrays, we analyzed the methylation profiles of pooled DNA from human cervical carcinoma and normal cervix Cervical carcinoma compaire with normal cervix

ORGANISM(S): Homo sapiens

SUBMITTER: Hung-Cheng Lai

PROVIDER: E-GEOD-33187 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Methylomic analysis identifies frequent DNA methylation of zinc finger protein 582 (ZNF582) in cervical neoplasms.

Huang Rui-Lan RL Chang Cheng-Chang CC Su Po-Hsuan PH Chen Yu-Chih YC Liao Yu-Ping YP Wang Hui-Chen HC Yo Yi-Te YT Chao Tai-Kuang TK Huang Hsuan-Cheng HC Lin Ching-Yu CY Chu Tang-Yuan TY Lai Hung-Cheng HC

PloS one 20120716 7

<h4>Background</h4>Despite of the trend that the application of DNA methylation as a biomarker for cancer detection is promising, clinically applicable genes are few. Therefore, we looked for novel hypermethylated genes for cervical cancer screening.<h4>Methods and findings</h4>At the discovery phase, we analyzed the methylation profiles of human cervical carcinomas and normal cervixes by methylated DNA immunoprecipitation coupled to promoter tiling arrays (MeDIP-on-chip). Methylation-specific P ...[more]

PMID: 22815913

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