Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Charlotte Esser
PROVIDER: E-GEOD-13130 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Jux Bettina B Kadow Stephanie S Esser Charlotte C
Journal of immunology (Baltimore, Md. : 1950) 20090601 11
Langerhans cells (LC) are professional APCs of the epidermis. Recently, it was suggested that they are tolerogenic and control adverse immune reactions, including against low molecular mass chemicals. The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, is involved in low molecular mass chemical metabolism and cell differentiation. Growing evidence suggests a role for the AhR in the immune system, for example, by influencing dendritic cell and T cell differentiation. We ...[more]