Tryptamine Serves As a Proligand of the AhR Transcriptional Pathway, and the Activation Is Dependent of Monoamine Oxidases
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Bernward Klocke
PROVIDER: E-GEOD-39812 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Tryptamine serves as a proligand of the AhR transcriptional pathway whose activation is dependent of monoamine oxidases.
Vikström Bergander Linda L Cai Wen W Klocke Bernward B Seifert Martin M Pongratz Ingemar I
Molecular endocrinology (Baltimore, Md.) 20120803 9
The function of the aryl hydrocarbon receptor (AhR) in mediating the biological effect to environmental pollutants is well established. However, accumulated evidence indicates a wide range of physiological and pathological functions mediated by the AhR, suggesting the existence of endogenous AhR ligand(s). The nature of an AhR ligand remain elusive; however, it is known that the AhR is activated by several compounds, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin or the tryptophan photoproduct 6-fo ...[more]
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