Mouse Sirt6-/- TNF-alpha timecourse
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Tiara Kawahara
PROVIDER: E-GEOD-13207 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.
Kawahara Tiara L A TL Michishita Eriko E Adler Adam S AS Damian Mara M Berber Elisabeth E Lin Meihong M McCord Ron A RA Ongaigui Kristine C L KC Boxer Lisa D LD Chang Howard Y HY Chua Katrin F KF
Cell 20090101 1
Members of the sirtuin (SIRT) family of NAD-dependent deacetylases promote longevity in multiple organisms. Deficiency of mammalian SIRT6 leads to shortened life span and an aging-like phenotype in mice, but the underlying molecular mechanisms are unclear. Here we show that SIRT6 functions at chromatin to attenuate NF-kappaB signaling. SIRT6 interacts with the NF-kappaB RELA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-kappaB target gene promoters. In SIRT6-deficient cells, hyperace ...[more]
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