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Transcription profiling of mouse AKR/J x PyMT F1 versus DBA/2J x PyMT F1 tumors

ABSTRACT: F1 hybrids from (AKR/J x FVB/NJ) and (DBA/2J x FVB/NJ) outcrosses display a 20-fold difference in mammary tumor metastatic capacity, due to differences in inherited polymorphisms. Expression studies were performed to determine whether polymorphism-driven gene expression signatures predictive of outcome could be generated from mouse tumor tissues Experiment Overall Design: Mammary tumors from adult F1 animals from (AKR/J x PyMT) and (DBA/2J x PyMT) outcrosses was collected and arrayed on Affymetrics chip to identify basal differences in gene expression between the different genotypes

ORGANISM(S): Mus musculus

SUBMITTER: Kent Hunter

PROVIDER: E-GEOD-13221 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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