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Transcription profiling of mouse AKR/J x PyM F1 versus DBA/2J x PyMT tissues to investigate the effect of inherited polymorphism on prognostic gene expression signatures (super series)

ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE13221: (AKR/J x PyMT)F1 versus (DBA/2J x PyMT)F1 tumor expression data; GSE13222: (AKR/J x FVB/NJ)F1 versus (DBA/2J x FVB)F1 blood expression data; GSE13223: (AKR/J x FVB/NJ)F1 versus (DBA/2J x FVB)F1 bone marrow expression data; GSE13224: (AKR/J x FVB/NJ)F1 versus (DBA/2J x FVB)F1 lung expression data; GSE13225: (AKR/J x FVB/NJ)F1 versus (DBA/2J x FVB)F1 spleen expression data; GSE13227: (AKR/J x FVB/NJ)F1 versus (DBA/2J x FVB)F1 Thymus expression data; GSE13230: Met1 or DB7 tumor gene expression Experiment Overall Design: Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Kent Hunter

PROVIDER: E-GEOD-13231 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcription profiling of mouse AKR/J x FVB/NJ F1 versus DBA/2J x FVB F1 lung

Project description:F1 hybrids from (AKR/J x FVB/NJ) and (DBA/2J x FVB/NJ) outcrosses display a 20-fold difference in mammary tumor metastatic capacity, due to differences in inherited polymorphisms. Expression studies were performed to determine whether polymorphism-driven gene expression signatures predictive of outcome could be generated from normal tissues Experiment Overall Design: Lung from adult F1 animals from (AKR/J x FVB/NJ) and (DBA/2J x FVB/NJ) outcrosses was collected and arrayed on Affymetrics chip to identify basal differences in gene expression between the different genotypes

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