Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Manuel Santos
PROVIDER: E-GEOD-13369 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ceppi Maurizio M Pereira Patricia M PM Dunand-Sauthier Isabelle I Barras Emmanuèle E Reith Walter W Santos Manuel A MA Pierre Philippe P
Proceedings of the National Academy of Sciences of the United States of America 20090204 8
In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control immunity. Here, we show that in response to Lipopolysaccharides (LPS), several microRNAs (miRNAs) are regulated in human monocyte-derived dendritic cells. Among these miRNAs, miR-155 is highly up-regulated during maturation. Using LNA silencing combined to microarray technology, we have identified the Toll-like receptor/interleukin- ...[more]