Unknown,Transcriptomics,Genomics,Proteomics

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MiRNA expression profiling of human monocyte-derived dendritic cells (moDCs) during maturation


ABSTRACT: miRNA expression profiling of human monocyte-derived dendritic cells (moDCs) during maturation. Immature, 4h and 16h LPS-activated moDCs were used. In this study were analysed 2 biological samples of RNA extracted from 4h-post LPS stimulation moDCs and 2 bfrom 16h-post LPS stimulation. The RNA from 0h-post LPS stimulation were used as reference sample. Were also performed dye-swaps of each biological sample as technical replicates.

ORGANISM(S): Homo sapiens

SUBMITTER: Manuel Santos 

PROVIDER: E-GEOD-13369 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells.

Ceppi Maurizio M   Pereira Patricia M PM   Dunand-Sauthier Isabelle I   Barras Emmanuèle E   Reith Walter W   Santos Manuel A MA   Pierre Philippe P  

Proceedings of the National Academy of Sciences of the United States of America 20090204 8


In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control immunity. Here, we show that in response to Lipopolysaccharides (LPS), several microRNAs (miRNAs) are regulated in human monocyte-derived dendritic cells. Among these miRNAs, miR-155 is highly up-regulated during maturation. Using LNA silencing combined to microarray technology, we have identified the Toll-like receptor/interleukin-  ...[more]

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