Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcriptome responses of duodenal epithelial cells to endurance swimming in female rats.

ABSTRACT: Intestinal calcium absorption is the sole pathway to supply calcium to the body and duodenum is the most efficient site of calcium absorption. Endurance exercise with moderate intensity significantly increased the intestinal calcium absorption. The unloaded non-impact excercise, such as swimming may enhance calcium absorption. However, the cellular and molecular mechanisms of this change have not been investigated. Thus, a genome-wide study by using microarray should reveal changes in the expression of several transporter genes in the intestinal absorptive cells of swimming excercised rats. Keywords: Gene expression; Comparative genomic hybridization Twelve rats were randomly divided into control and swimming groups. Swimming rats were initially trained for a week until they could swim non stop 1 hour/day. Swimming frequency was 5 days/week for 2 weeks. The age-matched control remained sedentary for 2 weeks in a swimming pool. At the end of the swimming protocol, the intestinal segments of rats were removed for total RNA extraction and microarray study.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Kannikar Wongdee

PROVIDER: E-GEOD-13499 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Endurance swimming stimulates transepithelial calcium transport and alters the expression of genes related to calcium absorption in the intestine of rats.

Teerapornpuntakit Jarinthorn J Dorkkam Nitita N Wongdee Kannikar K Krishnamra Nateetip N Charoenphandhu Narattaphol N

American journal of physiology. Endocrinology and metabolism 20090127 4

Endurance impact exercise, e.g., running, is known to enhance the intestinal calcium absorption. However, nonimpact exercise, e.g., swimming, is more appropriate for osteoporotic patients with cardiovascular diseases or disorders of bone and joint, but the effect of swimming on the intestinal calcium transport was unknown. This study, therefore, aimed to investigate the transepithelial calcium transport and the expression of related genes in the intestine of rats trained to swim nonstop 1 h/day, ...[more]

PMID: 19176351

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Dataset Information

Transcriptome responses of duodenal epithelial cells to endurance swimming in female rats.

Publications

Endurance swimming stimulates transepithelial calcium transport and alters the expression of genes related to calcium absorption in the intestine of rats.

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