Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of rat heart samples from animals with physiological or pathological cardiac hypertrophy


ABSTRACT: Dahl salt-sensitive (DS) rats were obtained from Harlan Sprague Dawley Laboratory at 5 weeks of age. At 6 weeks of age, physiologic cardiac hypertrophy was generated by a; vigorous daily exercise regimen for 6 weeks (e group). The exercise protocol is based on those described previously with modifications (Wisloff U et al., 2001; Jin H et al., 1994). Rats were exercised daily for 6 weeks on a rodent treadmill (Exer-6M; Columbus Instruments). The exercise program consisted of three weeks of progressively strenuous exercise regimens; followed by three weeks of maintenance period, during which the rats were exercised at 16 m/min at a 5o incline for 90 minutes/day. All rats completed the exercise protocol. Pathological cardiac hypertrophy was generated by feeding a 6% NaCl diet to DS rats at 6 weeks of age (h group) (Inoko M et al., 1994). Control rats (c group) were age matched and sedentary DS rats fed normal rat chow. Read more at http://cardiogenomics.med.harvard.edu/groups/proj1/pages/rat_home.html

Note that files GSM11886.txt and GSM12308.txt, and files GSM11887.txt and GSM12309.txt as downloaded from GEO contain identical data.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Martina Schinke 

PROVIDER: E-GEOD-776 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2006-11-10 | E-TABM-166 | biostudies-arrayexpress
2009-11-16 | E-TABM-213 | biostudies-arrayexpress
2010-06-24 | E-GEOD-13499 | biostudies-arrayexpress
2020-04-09 | PXD017306 | Pride
2014-10-09 | E-GEOD-52516 | biostudies-arrayexpress
2021-12-28 | E-MTAB-11020 | biostudies-arrayexpress
2008-04-09 | E-GEOD-7640 | biostudies-arrayexpress
2015-02-01 | E-GEOD-54276 | biostudies-arrayexpress
2003-10-24 | GSE776 | GEO
2008-06-18 | E-GEOD-10527 | biostudies-arrayexpress