Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Gene expression analysis of Ox40-cre/ROSA-YFP CD4+ T cell subsets


ABSTRACT: An Ox40-cre allele was used for lineage marking of CD4 T cells. Naive T cells that had previously expressed OX40 demonstrated a partially activated phenotype that was distinct from that of the majority of naive T cells. These results are consistent with a minor subpopulation of naive T cells being dependent on strong signaling responses to thymic self ligands. Keywords: T cell population comparison. Characterization of a novel subpopulation of naive T cells. Four types of T cells were sorted from mice (naive, CD44lo, CD44hi and Treg).

ORGANISM(S): Mus musculus

SUBMITTER: Mark Klinger 

PROVIDER: E-GEOD-13502 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands.

Klinger Mark M   Kim Joong Kyu JK   Chmura Stephen A SA   Barczak Andrea A   Erle David J DJ   Killeen Nigel N  

Journal of immunology (Baltimore, Md. : 1950) 20090401 8


OX40 is a member of the TNF receptor family expressed on activated and regulatory T (Treg) cells. Using an Ox40-cre allele for lineage marking, we found that a subpopulation of naive T cells had also previously expressed OX40 in the thymus. Ox40-cre was induced in a small fraction of thymocytes that were OX40(+), some of which were CD25(high) Treg cell precursors. Thymic OX40 expression distinguished cells experiencing a strong signaling response to positive selection. Naive T cells that had pre  ...[more]

Similar Datasets

2009-09-22 | GSE13502 | GEO
2011-06-02 | E-GEOD-24574 | biostudies-arrayexpress
2024-05-23 | GSE182699 | GEO
2011-03-24 | E-GEOD-28165 | biostudies-arrayexpress
2024-05-23 | GSE267236 | GEO
2015-04-30 | GSE59281 | GEO
| PRJNA726762 | ENA
2015-04-30 | E-GEOD-59281 | biostudies-arrayexpress
2024-05-24 | GSE202226 | GEO
2018-05-15 | GSE104611 | GEO