Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Mark Klinger
PROVIDER: E-GEOD-13502 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Journal of immunology (Baltimore, Md. : 1950) 20090401 8
OX40 is a member of the TNF receptor family expressed on activated and regulatory T (Treg) cells. Using an Ox40-cre allele for lineage marking, we found that a subpopulation of naive T cells had also previously expressed OX40 in the thymus. Ox40-cre was induced in a small fraction of thymocytes that were OX40(+), some of which were CD25(high) Treg cell precursors. Thymic OX40 expression distinguished cells experiencing a strong signaling response to positive selection. Naive T cells that had pre ...[more]