Novel age related alterations revealed by a comparative kinetic transcriptome analysis of naïve CD4+ and CD8+ T cells from young and old animals.
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ABSTRACT: Define,(a) intrinsic differences and (b) changes occuring upon TCR activation in genetic profiles of naive CD4+ and CD8+ T cells from young and old animals, to identify candidate genes altered in old T cells involved in impairement of immune response in order to restore immune function in the old. Activation dependant time series on sorted naive (CD62Lhi/CD44lo) CD4 and CD8 T cells from young and old animals-Each time point contains RNA pooled from 4 independent sortings
ORGANISM(S): Mus musculus
SUBMITTER: Dominique Hoelzinger
PROVIDER: E-GEOD-28165 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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