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Transcription profiling time series of Rattus norvegicus femoral fracture healing in individuals aged 6, 26 and 52 weeks

ABSTRACT: A study of rat femoral fracture healing in young (6 weeks old at fracture), adult (26 weeks old at fracture), and old (52 weeks old at fracture) rats. Samples were collected at time of surgery (intact controls) and at 3 days, 1 week, 2 weeks, 4 weeks, and 6 weeks after fracture. Samples were the mid third of the femoral length including the external callus, cortical bone and marrow elements. Fracture was stabilized with an intramedullary rod prior to fracture with a Bonnarens and Einhorn device.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Ralph Meyer

PROVIDER: E-GEOD-1371 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Altered mRNA expression of genes related to nerve cell activity in the fracture callus of older rats: A randomized, controlled, microarray study.

Meyer Martha H MH Etienne Wiguins W Meyer Ralph A RA

BMC musculoskeletal disorders 20040803

<h4>Background</h4>The time required for radiographic union following femoral fracture increases with age in both humans and rats for unknown reasons. Since abnormalities in fracture innervation will slow skeletal healing, we explored whether abnormal mRNA expression of genes related to nerve cell activity in the older rats was associated with the slowing of skeletal repair.<h4>Methods</h4>Simple, transverse, mid-shaft, femoral fractures with intramedullary rod fixation were induced in anaesthet ...[more]

PMID: 15291962

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