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Transcription profiling of microdissected global and orbital layers of the rectus extraocular muscle (EOM) from adult Sprague-Dawley rats

ABSTRACT: Adult rat global and orbital layers of rectal extraocular muscles microdissected using Arcturus Pixcell II LCM are gene profiled here using affymetrix rat RAE230A gene chip. www.med.upenn.edu/cellbio/faculty/rubinstein/; www.uphs.upenn.edu/pmi/members/khurana/lab%20page.htm

ORGANISM(S): Rattus norvegicus

SUBMITTER: Murat Budak

PROVIDER: E-GEOD-1374 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Layer-specific differences of gene expression in extraocular muscles identified by laser-capture microscopy.

Budak Murat T MT Bogdanovich Sasha S Wiesen Martin H J MH Lozynska Olga O Khurana Tejvir S TS Rubinstein Neal A NA

Physiological genomics 20041005 1

In mammals, separate muscles are typically specialized as a whole to provide distinct functional roles leading to well-recognized adaptations. This is exemplified in the lower limb by the slow, fatigue-resistant soleus, which provides a postural role vs. the fast, fatiguable tibialis anterior (TA), which provides rapid movements. A unique characteristic of extraocular muscles (EOMs) is their compartmentalization into two distinct layers, the orbital layer (OL) and global layer (GL), presumably t ...[more]

PMID: 15467012

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