Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of mouse presenilin conditional double knockout cerebral cortex at 6 months old

ABSTRACT: Gene expression profile of presenilin conditional double knockout cerebral cortex, comparing to control. Age of mice: 6 months

ORGANISM(S): Mus musculus

SUBMITTER: Vassilios Beglopoulos

PROVIDER: E-GEOD-1375 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.

Beglopoulos Vassilios V Sun Xiaoyan X Saura Carlos A CA Lemere Cynthia A CA Kim Richard D RD Shen Jie J

The Journal of biological chemistry 20040901 45

Mutations in presenilins (PS) 1 and 2 are the major cause of familial Alzheimer's disease. Conditional double knock-out mice lacking both presenilins in the postnatal forebrain (PS cDKO mice) exhibit memory and synaptic plasticity impairments followed by progressive neurodegeneration in the cerebral cortex. Here we further investigate the molecular events that may underlie the observed phenotypes and identify additional neuropathological markers in the PS cDKO brain. Enzyme-linked immunosorbent ...[more]

PMID: 15345711

Similar Datasets

PS cDKO / Control, 6 months

Project description:Gene expression profile of presenilin conditional double knockout cerebral cortex, comparing to control. Age of mice: 6 months Keywords = presenilin knockout Keywords: parallel sample

2004-07-31 | GSE1375 | GEO

Effects of Conditional Egfr deletion on transcriptome of the mouse cerebral cortex

Project description:Effects of Conditional Egfr deletion on transcriptome of the mouse cerebral cortex

| PRJNA885310 | ENA

Effects of Conditional Egfr deletion on transcriptome of the mouse cerebral cortex

Project description:Effects of Conditional Egfr deletion on transcriptome of the mouse cerebral cortex

| PRJNA846729 | ENA

RNA-seq data of mouse cerebral cortex in control and UTX conditional knockout groups

Project description:RNA-seq data of mouse cerebral cortex in control and UTX conditional knockout groups

| PRJNA433664 | ENA

Gene expression in basal progenitors in the cerebral cortex of Tbr2 conditional knockout mice

Project description:Gene expression in basal progenitors in the cerebral cortex of Tbr2 conditional knockout mice

| PRJNA496025 | ENA

Chronic oral administration of nicotine affects transcriptomic profiling in conditional Presenilin 1/2 knockout mice and wild type mice

Project description:we found that chronic oral (3 months) administration of nicotine had different effects on transcriptomic profiling in prefrontal forebrain cortex of wildtype (WT) and Presenilin 1/2 double knockout mice.

2024-01-01 | GSE211983 | GEO

Expression data from mouse cerebral cortex

Project description:Differential gene expression of cerebral cortex might be responsible for distinct neurovascular developments between different mouse strains We used Affymetrix microarray to explore the global gene expression patterns of mouse cerebral cortex of different mouse strains at two developmental stages Cerebral cortex from two mouse strains [C57BL/6J(B6) and C3H/J (C3H)] at post-natal day 1 (p1) and post-natal 11 weeks (11 wk) were harvested for microarray experiments

2013-10-21 | E-GEOD-46443 | biostudies-arrayexpress

Transcription profiling of C. elegans presenilin model

Project description:Regulation of presenilin genes. Presenilins are intramembrane aspartic proteases. These proteases are critical proteins in pathogenesis of Alzheimer's disease. The function of recently identified presenilin-homologous proteases (IMPAS or SPP)s is unknown. Our preliminary data in C.elegans model suggested the role of these proteins in early-development and , perhaps, in pathway related- to cholesterol -regulated signalling (Grigorenko et al, 2004, PNAS). The overall goal is to determine pattern of gene expression alterations in cells with knock-out or knock-down presenilin related proteins (IMPAS). The cultured cells, C.elegans and mouse models are planned to be used in this study. Here , we will determine gene expression patterns in C.elegans strain NL2099, fed with bacteria HT115, producing dsRNA for Ce-imp-2 gene (knock-down of imp-2 gene by RNAi )or GFP gene as a control. We hypothesize that novel family of presenilin-related proteases is important for cholesterol-regulated intracellular signalling and early development (including CNS/neuronal development and function). C.elegans (strain NL2099) on L1 stage were placed on agarose plates with bacteria HT115, producing dsRNA for: 1) Ce-imp-2 gene; 2) GFP as a control gene. After 48 hours at 20C , worms were washed in M9 buffer and total RNA was isolated by TRIzol method.

2008-06-15 | E-GEOD-7354 | biostudies-arrayexpress

Gene expression profiles of presenilin deficient DP thymocytes

Project description:Notch1 signaling is an important regulator of cell fate in early stages of T cell development. Because Notch receptors can function redundantly, we sought an approach for inhibiting all endogenous Notch signaling in thymocytes. Upon ligand engagement, Notch receptors undergo two successive proteolytic cleavages, the second involving a Presenilin (PS) containing complex with -secretase activity that releases a small intracellular fragment of Notch. This activated form of Notch (NotchIC) translocates from the membrane to the nucleus, where it acts as a transcription factor, inducing the expression of multiple target genes . Since Presenilins are required for the activation of all four mammalian forms of Notch, we generated mice with deletions of both Presenilin1 and Presenilin2 genes, the only genes encoding Presenilin in the mouse genome. To target Notch inactivation specifically to developing T cells, we introduced Cd4-Cre to mediate Presenilin gene deletion in a tissue- and stage-specific manner. Direct target genes of Notch signaling are largely unknown, and are likely to be cell lineage and stage specific. Therefore in order to identify potential Notch target genes , we compared RNA of thymocytes at the CD4+CD8+ stage of development from H-2b transgenic 5CC7 TCR/ RAG2-deficient / Presenilin1flox/flox /PS2-/- mice, with and without Cd4-Cre. Keywords: presenilin, thymocytes, mouse

2007-09-14 | GSE6590 | GEO

Regulation of presenilin genes (rogae-affy-c.ele-431660)

2007-03-23 | GSE7354 | GEO