Gene expression profiling in arterial tissue from type 2 diabetic patients
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Vibe Skov
PROVIDER: E-GEOD-13760 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Fibulin-1 is a marker for arterial extracellular matrix alterations in type 2 diabetes.
Cangemi Claudia C Skov Vibe V Poulsen Michael Kjaer MK Funder Jonas J Twal Waleed O WO Gall Mari-Anne MA Hjortdal Vibeke V Jespersen Marie Louise ML Kruse Torben A TA Aagard Jan J Parving Hans-Henrik HH Knudsen Steen S Høilund-Carlsen Poul-Flemming PF Rossing Peter P Henriksen Jan Erik JE Argraves William Scott WS Rasmussen Lars Melholt LM
Clinical chemistry 20110916 11
<h4>Background</h4>Extracellular matrix alterations are important elements in the arterial changes seen in diabetes, being associated with increased vascular stiffness and the development of cardiovascular diseases. However, no biomarkers for diabetes-related arterial changes have been defined.<h4>Methods</h4>Mammary artery specimens from 17 men with type 2 diabetes and 18 nondiabetic individuals were used for microarray expression profiling, quantitative real-time PCR, immunoassay, and immunohi ...[more]
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