Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ido Amit
PROVIDER: E-GEOD-63341 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment.
Lavin Yonit Y Winter Deborah D Blecher-Gonen Ronnie R David Eyal E Keren-Shaul Hadas H Merad Miriam M Jung Steffen S Amit Ido I
Cell 20141201 6
Macrophages are critical for innate immune defense and also control organ homeostasis in a tissue-specific manner. They provide a fitting model to study the impact of ontogeny and microenvironment on chromatin state and whether chromatin modifications contribute to macrophage identity. Here, we profile the dynamics of four histone modifications across seven tissue-resident macrophage populations. We identify 12,743 macrophage-specific enhancers and establish that tissue-resident macrophages have ...[more]
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