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Transcription profiling of mpuse IL10-/- dendritic cells pulsed for 6h with 0, SEA, LPS, or co-pulsed with SEA/LPS together to compare changes in LPS-induced gene expression mediated by SEA (Schistosome soluble egg antigen)

ABSTRACT: IL10-/-DC pulsed for 6h with 0, SEA, LPS, or co-pulsed with SEA/LPS together to compare changes in LPS-induced gene expression mediated by SEA (Schistosome soluble egg antigen)

ORGANISM(S): Mus musculus

SUBMITTER: Colleen Kane

PROVIDER: E-GEOD-1382 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Helminth antigens modulate TLR-initiated dendritic cell activation.

Kane Colleen M CM Cervi Laura L Sun Jie J McKee Amy S AS Masek Katherine S KS Shapira Sagi S Hunter Christopher A CA Pearce Edward J EJ

Journal of immunology (Baltimore, Md. : 1950) 20041201 12

There is increasing awareness that helminth infections can ameliorate proinflammatory conditions. In part, this is due to their inherent ability to induce Th2 and, perhaps, regulatory T cell responses. However, recent evidence indicates that helminths also have direct anti-inflammatory effects on innate immune responses. In this study, we address this issue and show that soluble molecules from the eggs of the helminth parasite Schistosoma mansoni (SEA) suppress LPS-induced activation of immature ...[more]

PMID: 15585871

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