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Expression profiling of the host and the Ovine Herpesvirus 2 pathogen during malignant catarrhal fever of cattle

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE13852: Expression profiling of Bos taurus lymph nodes upon infection with Ovine Herpesvirus 2 GSE13853: Expression profiling of Ovine Herpesvirus 2-infected lymph nodes from Bos taurus Refer to individual Series

ORGANISM(S): Bos taurus

SUBMITTER: Hubert Rehrauer

PROVIDER: E-GEOD-13854 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Malignant catarrhal fever of cattle is associated with low abundance of IL-2 transcript and a predominantly latent profile of ovine herpesvirus 2 gene expression.

Meier-Trummer Claudia S CS Rehrauer Hubert H Franchini Marco M Patrignani Andrea A Wagner Ulrich U Ackermann Mathias M

PloS one 20090715 7

<h4>Background</h4>Malignant catarrhal fever (MCF) is a lethal disease of cattle, characterized by vasculitis, necrosis, and accumulation of activated, dysregulated cytotoxic lymphocytes in various tissues. Ovine gamma herpesvirus 2 (OvHV-2) is a causative agent of MCF, which may trigger the disease through immunopathogenic pathways. Lymphocytes are the main target of the virus. However, the pathogenic basis of the disease is still mysterious.<h4>Methods/findings</h4>We hypothesized that the gen ...[more]

PMID: 19603070

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Project description:Expression profiling of Ovine Herpesvirus 2-infected lymph nodes from Bos taurus

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